Opportunities to target mast cells in inflammatory diseases expand
نویسندگان
چکیده
Drugs that target mast cells could provide novel options to treat disorders involving chronic allergic inflammation.
منابع مشابه
MAST CELLS IN INFLAMMATORY AURAL POLYPS
This study investigated the presence of mast cells in inflammatory aural polyps using light microscopy. The number of mast cells was increased in all examined cases and varied from 2.33 to 41.54 per mm2• The cells were located most commonly around small blood vessels. Occurrence of mast cells was not different in various types of polyps, but their density was severely increased in active in...
متن کاملMast cells in allergic and inflammatory diseases.
Mast cells are important in the development of allergic and anaphylactic reactions, but also in acquired and innate immunity. There is also increasing evidence that mast cells participate in inflammatory diseases, where they can be activated by non-allergic triggers, such as neuropeptides and cytokines, often having synergistic effects as in the case of substance P (SP) and IL-33. Secretion of ...
متن کاملmast cells in inflammatory aural polyps
this study investigated the presence of mast cells in inflammatory aural polyps using light microscopy. the number of mast cells was increased in all examined cases and varied from 2.33 to 41.54 per mm2• the cells were located most commonly around small blood vessels. occurrence of mast cells was not different in various types of polyps, but their density was severely increased in active inflam...
متن کاملMast cells in the inflammatory connective tissue diseases
Objective: To detect mast cells in normal human skin and mast cell infiltration in skin biopsies in patients with systemic sclerosis, systemic lupus erythematosus, Raynaud’s phenomenon, and persons not suffering from any systemic disease. Material and methods: Paraffin histological sections were stained with toluidine blue and by immunoperoxidase method for the von Willebrand factor. Results: I...
متن کاملMast cells in inflammatory arthritis
Mast cells are present in limited numbers in normal human synovium, but in rheumatoid arthritis and other inflammatory joint diseases this population can expand to constitute 5% or more of all synovial cells. Recent investigations in a murine model have demonstrated that mast cells can have a critical role in the generation of inflammation within the joint. This finding highlights the results o...
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ژورنال
عنوان ژورنال: Biopharma Dealmakers
سال: 2021
ISSN: ['2730-6275', '2730-6283']
DOI: https://doi.org/10.1038/d43747-021-00176-x